I started setting my fatigue limits per positional group and wanted to see what everyone thought, whether it was too high for some positions or not:

QB-100
RB-60
WR/TE-55
OL-95
DL/LB/DB-65
K-100

I have all fatigue levels set for 52-55 (except QB and K - 100). This low number doesn't seem to lessen injuries on my teams. However, I did start mixing and matching personnel more...running/passing plays or blitz/man coverage... and I have noticed a small drop in the amount of injuries I'm seeing.

I don't think your numbers are way out of line, except maybe OL. I only say that because I seem to get many injuries from that position with the lower setting (55).

It's all relative to your roster and what you want. I have 4 DEs and 3 DTs that I want to rotate. I have the DL setting at 30. Not by choice but I have a RB returning from injury (low conditioning) and 2 backups that are decent. I have RB set at 25. All depends on your depth and how long you want your studs to play. Recommended is 50-60. If you have depth, drop it a bit. If not, bump it up. Just one dumb asses opinion.

I've found that if your setting is too low, your starters end up not playing in the 4th quarter because they never get back to the threshhold.