Does it matter on the current game engine? Am I just wasting my time setting these every game?

I never use to set them, but started doing it all the time..i feel like it does make a difference in execution.

I use it every week. Along with over-rides in combination with changing the plays to what i want to do that week. It feels like it works. Whether it actually does or not idk.

Once you set your keys, at the bottom of the page you can view what plays are being used in the keys that you chose for that situation.

Yes, the current game engine gives you a boost if you call the right key and gives the other team a boost if you call the wrong one.

Will there be any changes involving this in the new update?

I did add a few more places that use the run/pass key in their decision making in the next release.

Every game unless I’m a heavy favorite. Sucks to fiddle with the bar to get it to slide. Least favorite part of gameplanning but I feel it’s worth it against good opponents.

From a functional perspective, yes they matter, but from a game planning perspective it's better to stick to all Neutral. Why? Neutral doesn't penalize your defense when you guess wrong, and if your opponent over uses a play, your defense will switch to the right key.

I saw the current model being straight foward....what "places" are you referring to?

Extremely fast players could benefit from running a majority series of blends of pass keys combined with blitzes .