I've played around with the settings for my defensive line and linebackers, with a lower setting around 45 to keep guys fresh but it didnt seem to change rotation much more than a 60 setting did. What settings do most of you all prefer?

My settings are between 15 and 60, apart from QB and K, which are 100.

Usually between 20-45 (except QB & K) ... lower end of that during preseason, so everybody gets some play time. Depends on #/quality of players.

I just set all positions at 50, 35-40 preseason.

This is how mine look right now. They're getting tweaked a little bit all the time.

This is kinda what I was talking about in the other thread, I haven't tried swinging the bar from 0 to 100, but like you mention I haven't found much difference in substitutions when I move the bar from 30-50ish... which is why I'm wondering now about this hidden fatigue rating. For something to have such a dramatic effect on the game, be hidden and have very little direct control over.. that's not a good thing.