So, apparently there is a minimum number of players that are required to be active? I tried sitting a bunch of starters for the last game of the season, only for most to be active and play. So question is, what's the minimum required active players per game? Thanks in advance.

Hi Mac.
So Did some digging in the forums this question was brought up in May 2016. Seems 45 is the Min on game days. a user set it to 32 and the game set 45 active anyways.

Here the link..You can read about the findings-https://mfn32.myfootballnow.com/community/thread/1/1786?page=1#10948

Mind you its almost a year old.. Game could've changed by now.
Hope it helps.
Dash

Ah. Thanks. Yep. Checked the depth chart and it was 45. Good to know. Appreciate you looking it up Dash.

On the depth chart page under the bar on the top right, the numbers will be in red if you are in danger of the AI doing something.

Be aware though, it turns red at 45. And 45 is OK.

Yeah, but I'm always leery of going with 45 because it's red. If the Ai does something I would feel like it's my fault because I should have known..."if it's red, the Ai will do something".