I have so many injuries that I can't have 46 active players, so only 44 players are going to play next week... but is it a problem ? Will the CPU active two other players to bring my active roster to 46 or no ?

If their status is out.... iam not sure, but if they can walk the ai will reset your plan . Just activate the least injured and put them way low on the depth chart with high postional fatigue or sign some scrubs.

Not sure if anything has changed But the ai will reset and take over everything , so in my opinion it is not a good idea.

If they are 'out' you can put them on IR so they don't take up a roster spot (they still take up cap space); if they are not 'out' like Ray said you can keep the least injured active and just lower them in your depth chart.

So that's what I'm going to do, find two players to lower in the depth chart and hope they will sit all game long.